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[32] Australia A 2003 Phase IIb clinical human trial demonstrated in a group of seventy-nine volunteers that those who were administered [Nle 4 , D-Phe 7 ]-MSH daily for a period of three months had highly significant increases in skin-melanin while those who were not, did not

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Blackett JW, Rosenberg R, Mahadev S, Green PHR, Lebwohl B (2018) Adenoma detection is increased in the setting of melanosis coli